8V8D

Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 2

Summary for 8V8D

Entry DOI	10.2210/pdb8v8d/pdb
Related	8UT1 8UTB 8UZJ 8V80 8V82 8V86 8V88 8V89 8V8A 8V8C
EMDB information	43035
Descriptor	Neuronal acetylcholine receptor subunit alpha-7,Soluble cytochrome b562, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	ion channel, membrane protein, nicotinic receptor
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	343160.34
Authors	Burke, S.M.,Noviello, C.M.,Hibbs, R.E. (deposition date: 2023-12-05, release date: 2024-02-21, Last modification date: 2024-03-13)
Primary citation	Burke, S.M.,Avstrikova, M.,Noviello, C.M.,Mukhtasimova, N.,Changeux, J.P.,Thakur, G.A.,Sine, S.M.,Cecchini, M.,Hibbs, R.E. Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation. Cell, 187:1160-1176.e21, 2024 Cited by PubMed: 38382524 DOI: 10.1016/j.cell.2024.01.032 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.31 Å)

Structure validation