8V4H

X-ray structure of the NADP-dependent reductase from Campylobacter jejuni responsible for the synthesis of CDP-glucitol in the presence of CDP-glucitol

Summary for 8V4H

• Entry DOI: 10.2210/pdb8v4h/pdb
• Related: 5v4g
• Descriptor: Putative nucleotide sugar dehydratase, [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-2,3,4,5,6-pentakis(oxidanyl)hexyl] hydrogen phosphate, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: capsular polysaccharide, short chain dehydrogenase, oxidoreductase
• Biological source: Campylobacter jejuni
• Total number of polymer chains: 2
• Total formula weight: 83512.10

Authors

Thoden, J.B.,Schumann, M.E.,Holden, H.M.,Raushel, F.M. (deposition date: 2023-11-29, release date: 2023-12-20, Last modification date: 2024-03-13)

• Primary citation: Ghosh, M.K.,Narindoshvili, T.,Thoden, J.B.,Schumann, M.E.,Holden, H.M.,Raushel, F.M.; Biosynthesis of Cytidine Diphosphate-6-d-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni.; Biochemistry, 63:699-710, 2024; PubMed: 38386885; DOI: 10.1021/acs.biochem.3c00706

Experimental method

X-RAY DIFFRACTION (2.2 Å)