8V2N

Human SIRT3 co-crystallized with ligands, including p53-AMC peptide and Carba-NAD

Summary for 8V2N

• Entry DOI: 10.2210/pdb8v2n/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, GLN-PRO-LYS-FDL, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: activator, complex, deacylase, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 32767.77

Authors

Chakrabarti, R.,Ghosh, A.,Guan, X.,Upadhyay, A.,Dumpati, R.K.,Munshi, S.,Roy, S.,Chall, S.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T. (deposition date: 2023-11-23, release date: 2023-12-06)

• Primary citation: Chakrabarti, R.,Ghosh, A.,Guan, X.,Upadhyay, A.,Dumpati, R.K.,Munshi, S.,Roy, S.,Chall, S.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T.; Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion; biorxiv, 2023; DOI: 10.1101/2023.11.09.566481

Experimental method

X-RAY DIFFRACTION (1.74 Å)