8UK6

Candida albicans glutaminyl tRNA synthetase (GLN4) in complex with N-pyrimidinyl-beta-thiophenylacrylamide

Summary for 8UK6

• Entry DOI: 10.2210/pdb8uk6/pdb
• Descriptor: glutamine--tRNA ligase, ZINC ION, (2E)-N-(pyrimidin-2-yl)-3-(thiophen-2-yl)prop-2-enamide, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, allosteric, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Candida albicans
• Total number of polymer chains: 1
• Total formula weight: 93783.95

Authors

Sychantha, D.,Wright, G.D. (deposition date: 2023-10-12, release date: 2024-03-06)

• Primary citation: Puumala, E.,Sychantha, D.,Lach, E.,Reeves, S.,Nabeela, S.,Fogal, M.,Nigam, A.,Johnson, J.W.,Aspuru-Guzik, A.,Shapiro, R.S.,Uppuluri, P.,Kalyaanamoorthy, S.,Magolan, J.,Whitesell, L.,Robbins, N.,Wright, G.D.,Cowen, L.E.; Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-beta-thiophenylacrylamides exerts highly selective antifungal activity.; Cell Chem Biol, 2024; PubMed: 38402621; DOI: 10.1016/j.chembiol.2024.01.010

Experimental method

X-RAY DIFFRACTION (2.73 Å)