8TY1

Cryo-EM structure of coagulation factor VIII bound to NB2E9

Summary for 8TY1

• Entry DOI: 10.2210/pdb8ty1/pdb
• EMDB information: 41710
• Descriptor: Coagulation factor VIII, NB2E9 light chain, NB2E9 heavy chain, ... (4 entities in total)
• Functional Keywords: coagulation, inhibitor antibody, factor viii, blood clotting-inhibitor complex, blood clotting/inhibitor
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 3
• Total formula weight: 219419.54

Authors

Childers, K.C.,Spiegel, P.C. (deposition date: 2023-08-24, release date: 2023-09-13)

• Primary citation: Childers, K.C.,Vaughan, J.,McGill, J.,Davulcu, O.,Lollar, P.,Doering, C.B.,Coxon, C.H.,Spiegel, P.C.; Structural basis for inhibition of coagulation factor VIII reveals a shared immunogenic hot-spot on the C1 domain; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.46 Å)