8TTW

Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074

Summary for 8TTW

• Entry DOI: 10.2210/pdb8ttw/pdb
• EMDB information: 41613
• Descriptor: Envelope glycoprotein gp160, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: bg505 sosip, 8anc195, 10-1074, bms-626529, temsavir, viral protein-inhibitor-immune system complex, viral protein/inhibitor/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 18
• Total formula weight: 539159.23

Authors

Tolbert, W.D.,Pozharski, E.,Pazgier, M. (deposition date: 2023-08-15, release date: 2023-11-08)

• Primary citation: Prevost, J.,Chen, Y.,Zhou, F.,Tolbert, W.D.,Gasser, R.,Medjahed, H.,Nayrac, M.,Nguyen, D.N.,Gottumukkala, S.,Hessell, A.J.,Rao, V.B.,Pozharski, E.,Huang, R.K.,Matthies, D.,Finzi, A.,Pazgier, M.; Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.; Nat Commun, 14:6710-6710, 2023; PubMed: 37872202; DOI: 10.1038/s41467-023-42500-2

Experimental method

ELECTRON MICROSCOPY (2.96 Å)