8TLC

Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor

Summary for 8TLC

• Entry DOI: 10.2210/pdb8tlc/pdb
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid (3 entities in total)
• Functional Keywords: shmt2, tetramer, glycine synthesis, inhibitor, polyglutamate, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 110399.77

Authors

Katinas, J.M.,Dann III, C.E. (deposition date: 2023-07-26, release date: 2024-02-21)

• Primary citation: Katinas, J.M.,Nayeen, M.J.,Schneider, M.,Shah, K.,Fifer, A.N.,Klapper, L.M.,Sharma, A.,Thalluri, K.,Van Nieuwenhze, M.S.,Hou, Z.,Gangjee, A.,Matherly, L.H.,Dann 3rd, C.E.; Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.; Biochemistry, 2024; PubMed: 38324671; DOI: 10.1021/acs.biochem.3c00613

Experimental method

X-RAY DIFFRACTION (2.72 Å)