8TF4

Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole

Summary for 8TF4

Entry DOI	10.2210/pdb8tf4/pdb
EMDB information	41219
Descriptor	Transient receptor potential cation channel subfamily V member 5, ERGOSTEROL, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (4 entities in total)
Functional Keywords	trpv5, trp channel, pi(4, 5)p2, econazole, membrane protein
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	4
Total formula weight	345902.74
Authors	De Jesus-Perez, J.J.,Fluck, E.C.,Moiseenkova-Bell, V.Y. (deposition date: 2023-07-07, release date: 2024-01-10, Last modification date: 2024-02-14)
Primary citation	De Jesus-Perez, J.J.,Gabrielle, M.,Raheem, S.,Fluck, E.C.,Rohacs, T.,Moiseenkova-Bell, V.Y. Structural mechanism of TRPV5 inhibition by econazole. Structure, 32:148-156.e5, 2024 Cited by PubMed: 38141613 DOI: 10.1016/j.str.2023.11.012 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.86 Å)

Structure validation