8TC8

Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate

Summary for 8TC8

• Entry DOI: 10.2210/pdb8tc8/pdb
• Descriptor: Asparagine--tRNA ligase, cytoplasmic, 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: enzyme, ligase, synthase, drug target
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 255518.37

Authors

Dogovski, C.,Metcalfe, R.D.,Xie, S.C.,Morton, C.J.,Tilley, L.,Griffin, M.D.W. (deposition date: 2023-06-30, release date: 2024-02-07, Last modification date: 2024-02-14)

• Primary citation: Xie, S.C.,Wang, Y.,Morton, C.J.,Metcalfe, R.D.,Dogovski, C.,Pasaje, C.F.A.,Dunn, E.,Luth, M.R.,Kumpornsin, K.,Istvan, E.S.,Park, J.S.,Fairhurst, K.J.,Ketprasit, N.,Yeo, T.,Yildirim, O.,Bhebhe, M.N.,Klug, D.M.,Rutledge, P.J.,Godoy, L.C.,Dey, S.,De Souza, M.L.,Siqueira-Neto, J.L.,Du, Y.,Puhalovich, T.,Amini, M.,Shami, G.,Loesbanluechai, D.,Nie, S.,Williamson, N.,Jana, G.P.,Maity, B.C.,Thomson, P.,Foley, T.,Tan, D.S.,Niles, J.C.,Han, B.W.,Goldberg, D.E.,Burrows, J.,Fidock, D.A.,Lee, M.C.S.,Winzeler, E.A.,Griffin, M.D.W.,Todd, M.H.,Tilley, L.; Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.; Nat Commun, 15:937-937, 2024; PubMed: 38297033; DOI: 10.1038/s41467-024-45224-z

Experimental method

X-RAY DIFFRACTION (1.9 Å)