8TBL

Tricomplex of RMC-7977, KRAS G12D, and CypA

Summary for 8TBL

Entry DOI	10.2210/pdb8tbl/pdb
Descriptor	GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
Functional Keywords	inhibitor, complex, small gtpase, cancer, tricomplex, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	77859.87
Authors	Tomlinson, A.C.A.,Chen, A.,Knox, J.E.,Yano, J.K. (deposition date: 2023-06-28, release date: 2024-02-07, Last modification date: 2024-04-24)
Primary citation	Holderfield, M.,Lee, B.J.,Jiang, J.,Tomlinson, A.,Seamon, K.J.,Mira, A.,Patrucco, E.,Goodhart, G.,Dilly, J.,Gindin, Y.,Dinglasan, N.,Wang, Y.,Lai, L.P.,Cai, S.,Jiang, L.,Nasholm, N.,Shifrin, N.,Blaj, C.,Shah, H.,Evans, J.W.,Montazer, N.,Lai, O.,Shi, J.,Ahler, E.,Quintana, E.,Chang, S.,Salvador, A.,Marquez, A.,Cregg, J.,Liu, Y.,Milin, A.,Chen, A.,Ziv, T.B.,Parsons, D.,Knox, J.E.,Klomp, J.E.,Roth, J.,Rees, M.,Ronan, M.,Cuevas-Navarro, A.,Hu, F.,Lito, P.,Santamaria, D.,Aguirre, A.J.,Waters, A.M.,Der, C.J.,Ambrogio, C.,Wang, Z.,Gill, A.L.,Koltun, E.S.,Smith, J.A.M.,Wildes, D.,Singh, M. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 2024 Cited by PubMed: 38589574 DOI: 10.1038/s41586-024-07205-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation