8TBH

Tricomplex of RMC-7977, KRAS G12R, and CypA

Summary for 8TBH

• Entry DOI: 10.2210/pdb8tbh/pdb
• Descriptor: GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, small gtpase, cancer, tricomplex, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 77988.31

Authors

Bar Ziv, T.,Zhang, D.,Tomlinson, A.C.A.,Knox, J.E.,Yano, J.K. (deposition date: 2023-06-28, release date: 2024-02-07, Last modification date: 2024-04-24)

• Primary citation: Holderfield, M.,Lee, B.J.,Jiang, J.,Tomlinson, A.,Seamon, K.J.,Mira, A.,Patrucco, E.,Goodhart, G.,Dilly, J.,Gindin, Y.,Dinglasan, N.,Wang, Y.,Lai, L.P.,Cai, S.,Jiang, L.,Nasholm, N.,Shifrin, N.,Blaj, C.,Shah, H.,Evans, J.W.,Montazer, N.,Lai, O.,Shi, J.,Ahler, E.,Quintana, E.,Chang, S.,Salvador, A.,Marquez, A.,Cregg, J.,Liu, Y.,Milin, A.,Chen, A.,Ziv, T.B.,Parsons, D.,Knox, J.E.,Klomp, J.E.,Roth, J.,Rees, M.,Ronan, M.,Cuevas-Navarro, A.,Hu, F.,Lito, P.,Santamaria, D.,Aguirre, A.J.,Waters, A.M.,Der, C.J.,Ambrogio, C.,Wang, Z.,Gill, A.L.,Koltun, E.S.,Smith, J.A.M.,Wildes, D.,Singh, M.; Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.; Nature, 2024; PubMed: 38589574; DOI: 10.1038/s41586-024-07205-6

Experimental method

X-RAY DIFFRACTION (1.5 Å)