8T75
Crystal Structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD-CRD)
Summary for 8T75
Entry DOI | 10.2210/pdb8t75/pdb |
Descriptor | GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total) |
Functional Keywords | kras, ras, raf1, craf, oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 147967.53 |
Authors | Whitley, M.J.,Simanshu, D.K. (deposition date: 2023-06-19, release date: 2024-02-14, Last modification date: 2024-02-28) |
Primary citation | Whitley, M.J.,Tran, T.H.,Rigby, M.,Yi, M.,Dharmaiah, S.,Waybright, T.J.,Ramakrishnan, N.,Perkins, S.,Taylor, T.,Messing, S.,Esposito, D.,Nissley, D.V.,McCormick, F.,Stephen, A.G.,Turbyville, T.,Cornilescu, G.,Simanshu, D.K. Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Sci Adv, 10:eadj4137-eadj4137, 2024 Cited by PubMed: 38354232DOI: 10.1126/sciadv.adj4137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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