8T74
Crystal structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD)
Summary for 8T74
Entry DOI | 10.2210/pdb8t74/pdb |
Descriptor | GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | ras, kras, raf1, craf, oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 30079.27 |
Authors | Whitley, M.J.,Simanshu, D.K. (deposition date: 2023-06-19, release date: 2024-02-14, Last modification date: 2024-02-28) |
Primary citation | Whitley, M.J.,Tran, T.H.,Rigby, M.,Yi, M.,Dharmaiah, S.,Waybright, T.J.,Ramakrishnan, N.,Perkins, S.,Taylor, T.,Messing, S.,Esposito, D.,Nissley, D.V.,McCormick, F.,Stephen, A.G.,Turbyville, T.,Cornilescu, G.,Simanshu, D.K. Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Sci Adv, 10:eadj4137-eadj4137, 2024 Cited by PubMed: 38354232DOI: 10.1126/sciadv.adj4137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report