8T4V

Crystal structure of compound 1 bound to K-Ras(G12D)

Summary for 8T4V

• Entry DOI: 10.2210/pdb8t4v/pdb
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, covalent, gtpase, oncoprotein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 45248.60

Authors

Zhang, Z.,Zheng, Q.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2023-06-10, release date: 2024-03-13)

• Primary citation: Zheng, Q.,Zhang, Z.,Guiley, K.Z.,Shokat, K.M.; Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.; Nat.Chem.Biol., 2024; PubMed: 38443470; DOI: 10.1038/s41589-024-01565-w

Experimental method

X-RAY DIFFRACTION (1.47 Å)