8T4P
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and di-glutamate AGF347 inhibitor
Summary for 8T4P
Entry DOI | 10.2210/pdb8t4p/pdb |
Descriptor | Serine hydroxymethyltransferase, mitochondrial, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-gamma-glutamyl-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | mitochondrial, one-carbon metabolism, polyglutamate, inhibitor, complex, serine and glycine metabolism, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 110486.88 |
Authors | |
Primary citation | Katinas, J.M.,Nayeen, M.J.,Schneider, M.,Shah, K.,Fifer, A.N.,Klapper, L.M.,Sharma, A.,Thalluri, K.,Van Nieuwenhze, M.S.,Hou, Z.,Gangjee, A.,Matherly, L.H.,Dann 3rd, C.E. Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry, 2024 Cited by PubMed: 38324671DOI: 10.1021/acs.biochem.3c00613 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.801 Å) |
Structure validation
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