8SZJ

Human glutaminase C (Y466W) with L-Gln and Pi, filamentous form

Summary for 8SZJ

Entry DOI	10.2210/pdb8szj/pdb
EMDB information	40918
Descriptor	Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION, GLUTAMINE (3 entities in total)
Functional Keywords	cancer, filament, metabolism, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	12
Total formula weight	789660.82
Authors	Feng, S.,Aplin, C.,Nguyen, T.-T.T.,Milano, S.K.,Cerione, R.A. (deposition date: 2023-05-29, release date: 2024-03-13)
Primary citation	Feng, S.,Aplin, C.,Nguyen, T.T.,Milano, S.K.,Cerione, R.A. Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15:1971-1971, 2024 Cited by PubMed: 38438397 DOI: 10.1038/s41467-024-46351-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.35 Å)

Structure validation