8STR

Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) varient in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a non-nucleoside inhibitor

Summary for 8STR

• Entry DOI: 10.2210/pdb8str/pdb
• Related: 8STP 8STQ
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-7-fluoronaphthalene-2-carbonitrile, ... (4 entities in total)
• Functional Keywords: reverse transcriptase, antiviral, drug design, hiv-1, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 2
• Total formula weight: 114404.08

Authors

Hollander, K.,Chan, A.H.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-05-11, release date: 2023-11-29, Last modification date: 2023-12-13)

• Primary citation: Hollander, K.,Chan, A.H.,Frey, K.M.,Hunker, O.,Ippolito, J.A.,Spasov, K.A.,Yeh, Y.J.,Jorgensen, W.L.,Ho, Y.C.,Anderson, K.S.; Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise.; Protein Sci., 32:e4814-e4814, 2023; PubMed: 37861472; DOI: 10.1002/pro.4814

Experimental method

X-RAY DIFFRACTION (2.77 Å)