8SQF

OXA-48 bound to inhibitor CDD-2725

Summary for 8SQF

Entry DOI	10.2210/pdb8sqf/pdb
Descriptor	Beta-lactamase, (1M)-3'-(benzyloxy)-5-hydroxy[1,1'-biphenyl]-3,4'-dicarboxylic acid, BICARBONATE ION, ... (4 entities in total)
Functional Keywords	carbapenemase, beta-lactamase, small molecule, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	2
Total formula weight	61730.18
Authors	Park, S.,Judge, A.,Fan, J.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2023-05-04, release date: 2024-01-03, Last modification date: 2024-01-17)
Primary citation	Park, S.,Fan, J.,Chamakuri, S.,Palaniappan, M.,Sharma, K.,Qin, X.,Wang, J.,Tan, Z.,Judge, A.,Hu, L.,Sankaran, B.,Li, F.,Prasad, B.V.V.,Matzuk, M.M.,Palzkill, T. Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J.Med.Chem., 67:620-642, 2024 Cited by PubMed: 38117688 DOI: 10.1021/acs.jmedchem.3c01834 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation