8SPN

Crystal structure of macrophage migration inhibitory factor in complex with T614

Summary for 8SPN

• Entry DOI: 10.2210/pdb8spn/pdb
• Descriptor: Macrophage migration inhibitory factor, SULFATE ION, ISOPROPYL ALCOHOL, ... (6 entities in total)
• Functional Keywords: inhibitor, enzyme, complex, isomerase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 37783.85

Authors

Pantouris, G.,Lolis, E. (deposition date: 2023-05-03, release date: 2024-05-01)

• Primary citation: Bloom, J.,Pantouris, G.,He, M.,Aljabari, B.,Mishra, L.,Manjula, R.,Parkins, A.,Lolis, E.J.,Al-Abed, Y.; Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.; Mol Med, 30:43-43, 2024; PubMed: 38539088; DOI: 10.1186/s10020-024-00803-0

Experimental method

X-RAY DIFFRACTION (1.73 Å)