8SLO

Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673

Summary for 8SLO

Entry DOI	10.2210/pdb8slo/pdb
Descriptor	M1 family aminopeptidase, ZINC ION, 2-hydroxy-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-2-methylpropanamide, ... (6 entities in total)
Functional Keywords	plasmodium falciparum, malaria, metallo-exopeptidase, m1 aminopeptidase, aminopeptidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	1
Total formula weight	127849.26
Authors	McGowan, S.M.,Drinkwater, N. (deposition date: 2023-04-24, release date: 2024-04-03)
Primary citation	Giannangelo, C.,Drinkwater, N.,Edgar, R.,Malcolm, T.R.,Siddiqui, G.,Scammells, P.J.,De Koning-Ward, T.F.,McGowan, S.,Creek, D. Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as a cross-species strategy to treat malaria Elife, 2024 Cited by DOI: 10.7554/eLife.92990.1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation