8SDZ

Structure of rat organic anion transporter 1 (OAT1) in complex with probenecid

Summary for 8SDZ

• Entry DOI: 10.2210/pdb8sdz/pdb
• EMDB information: 40355
• Descriptor: Solute carrier family 22 member 6, 4-(dipropylsulfamoyl)benzoic acid (3 entities in total)
• Functional Keywords: organic anion transporter, oat, slc22, drug transporter, probenecid, transport protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 61102.19

Authors

Dou, T.,Jiang, J. (deposition date: 2023-04-07, release date: 2023-10-18, Last modification date: 2023-11-22)

• Primary citation: Dou, T.,Lian, T.,Shu, S.,He, Y.,Jiang, J.; The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.; Nat.Struct.Mol.Biol., 30:1794-1805, 2023; PubMed: 37845412; DOI: 10.1038/s41594-023-01123-3

Experimental method

ELECTRON MICROSCOPY (2.86 Å)