8SDY

Structure of rat organic anion transporter 1 (OAT1) in complex with para-aminohippuric acid (PAH)

Summary for 8SDY

Entry DOI	10.2210/pdb8sdy/pdb
EMDB information	40354
Descriptor	Solute carrier family 22 member 6, N-(4-aminobenzoyl)glycine (3 entities in total)
Functional Keywords	organic anion transporter, oat, slc22, drug transporter, pah, transport protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	1
Total formula weight	61011.02
Authors	Dou, T.,Jiang, J. (deposition date: 2023-04-07, release date: 2023-10-18, Last modification date: 2023-11-22)
Primary citation	Dou, T.,Lian, T.,Shu, S.,He, Y.,Jiang, J. The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM. Nat.Struct.Mol.Biol., 30:1794-1805, 2023 Cited by PubMed: 37845412 DOI: 10.1038/s41594-023-01123-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.79 Å)

Structure validation