8SC4

Human OCT1 bound to metformin in inward-open conformation

Summary for 8SC4

Entry DOI	10.2210/pdb8sc4/pdb
EMDB information	40337
Descriptor	Solute carrier family 22 member 1, Metformin (2 entities in total)
Functional Keywords	membrane protein, mfs, drug transporter, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	61329.83
Authors	Zeng, Y.C.,Sobti, M.,Stewart, A.G. (deposition date: 2023-04-04, release date: 2023-10-18, Last modification date: 2023-10-25)
Primary citation	Zeng, Y.C.,Sobti, M.,Quinn, A.,Smith, N.J.,Brown, S.H.J.,Vandenberg, J.I.,Ryan, R.M.,O'Mara, M.L.,Stewart, A.G. Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. Nat Commun, 14:6374-6374, 2023 Cited by PubMed: 37821493 DOI: 10.1038/s41467-023-42086-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.46 Å)

Structure validation