8RQ4

Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid

Summary for 8RQ4

Entry DOI	10.2210/pdb8rq4/pdb
EMDB information	19433
Descriptor	ATP-binding cassette sub-family C member 2, CHOLESTEROL HEMISUCCINATE, 4-(dipropylsulfamoyl)benzoic acid (3 entities in total)
Functional Keywords	multidrug resistance-associated protein 2 (rmrp2) in an autoinhibited state (nucleotide-free), transport protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	1
Total formula weight	174629.02
Authors	Mazza, T.,Beis, K. (deposition date: 2024-01-17, release date: 2024-02-14, Last modification date: 2024-03-13)
Primary citation	Mazza, T.,Roumeliotis, T.I.,Garitta, E.,Drew, D.,Rashid, S.T.,Indiveri, C.,Choudhary, J.S.,Linton, K.J.,Beis, K. Structural basis for the modulation of MRP2 activity by phosphorylation and drugs. Nat Commun, 15:1983-1983, 2024 Cited by PubMed: 38438394 DOI: 10.1038/s41467-024-46392-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.45 Å)

Structure validation