8RKF

Crystal structure of the ZP-N1 and ZP-N2 domains of human ZP2 (hZP2-N1N2)

Summary for 8RKF

• Entry DOI: 10.2210/pdb8rkf/pdb
• Related: 5BUP 5II6 8RKE 8RKG 8RKH
• EMDB information: 19276 19277
• Descriptor: Zona pellucida sperm-binding protein 2, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: cell adhesion, fertilization, egg-sperm interaction, gamete recognition, sperm receptor, extracellular matrix, egg coat, zona pellucida, glycoprotein, n-glycan, structural protein, zp-n domain, block to polyspermy, post-fertilization cleavage, ovastacin
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 53504.81

Authors

Dioguardi, E.,Stsiapanava, A.,de Sanctis, D.,Jovine, L. (deposition date: 2023-12-25, release date: 2024-03-13, Last modification date: 2024-03-27)

• Primary citation: Nishio, S.,Emori, C.,Wiseman, B.,Fahrenkamp, D.,Dioguardi, E.,Zamora-Caballero, S.,Bokhove, M.,Han, L.,Stsiapanava, A.,Algarra, B.,Lu, Y.,Kodani, M.,Bainbridge, R.E.,Komondor, K.M.,Carlson, A.E.,Landreh, M.,de Sanctis, D.,Yasumasu, S.,Ikawa, M.,Jovine, L.; ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.; Cell, 187:1440-1459.e24, 2024; PubMed: 38490181; DOI: 10.1016/j.cell.2024.02.013

Experimental method

X-RAY DIFFRACTION (3.2 Å)