8R4X

Structure of Chitinase-3-like protein 1 in complex with inhibitor 30

Summary for 8R4X

Entry DOI	10.2210/pdb8r4x/pdb
Descriptor	Chitinase-3-like protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	chitinase-3-like-1, protein-inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	175238.04
Authors	Nowak, E.,Napiorkowska-Gromadzka, A.,Nowotny, M. (deposition date: 2023-11-14, release date: 2024-03-13, Last modification date: 2024-03-27)
Primary citation	Czestkowski, W.,Krzeminski, L.,Piotrowicz, M.C.,Mazur, M.,Pluta, E.,Andryianau, G.,Koralewski, R.,Matyszewski, K.,Olejniczak, S.,Kowalski, M.,Lisiecka, K.,Koziel, R.,Piwowar, K.,Papiernik, D.,Nowotny, M.,Napiorkowska-Gromadzka, A.,Nowak, E.,Niedzialek, D.,Wieczorek, G.,Siwinska, A.,Rejczak, T.,Jedrzejczak, K.,Mulewski, K.,Olczak, J.,Zaslona, Z.,Golebiowski, A.,Drzewicka, K.,Bartoszewicz, A. Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1. J.Med.Chem., 67:3959-3985, 2024 Cited by PubMed: 38427954 DOI: 10.1021/acs.jmedchem.3c02255 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation