8R4B

Roco protein from C. tepidum in the GTP state bound to the activating Nanobodies NbRoco1 and NbRoco2

Summary for 8R4B

• Entry DOI: 10.2210/pdb8r4b/pdb
• Related: 8R4C 8R4D
• EMDB information: 18879 18884
• Descriptor: Rab family protein, NbRoco1, NbRoco2, ... (4 entities in total)
• Functional Keywords: gtpase, nanobody, parkinson's disease, allostery activator, hydrolase
• Biological source: Chlorobaculum tepidum; More
• Total number of polymer chains: 3
• Total formula weight: 154240.16

Authors

Galicia, C.,Versees, W. (deposition date: 2023-11-13, release date: 2024-05-01, Last modification date: 2024-05-08)

• Primary citation: Galicia, C.,Guaitoli, G.,Fislage, M.,Gloeckner, C.J.,Versees, W.; Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies.; Elife, 13:-, 2024; PubMed: 38666771; DOI: 10.7554/eLife.94503

Experimental method

ELECTRON MICROSCOPY (3.88 Å)