8R1L

Structure of avian H5N1 influenza A polymerase in complex with human ANP32B.

Summary for 8R1L

Entry DOI	10.2210/pdb8r1l/pdb
EMDB information	18822
Descriptor	Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ... (4 entities in total)
Functional Keywords	influenza virus, replication platform, h5n1, influenza adaptive mutations, host adaptation, viral polymerase, cryo-em, hpai., viral protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	299413.26
Authors	Carrique, L.,Staller, E.,Keown, J.R.,Fan, H.,Fodor, E.,Grimes, J.M. (deposition date: 2023-11-02, release date: 2024-05-08, Last modification date: 2024-05-29)
Primary citation	Staller, E.,Carrique, L.,Swann, O.C.,Fan, H.,Keown, J.R.,Sheppard, C.M.,Barclay, W.S.,Grimes, J.M.,Fodor, E. Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation. Nat Commun, 15:4123-4123, 2024 Cited by PubMed: 38750014 DOI: 10.1038/s41467-024-48470-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation