8QYR
Beta-cardiac myosin motor domain in the pre-powerstroke state complexed to Mavacamten
Summary for 8QYR
Entry DOI | 10.2210/pdb8qyr/pdb |
Descriptor | Myosin-7, 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione, SULFATE ION, ... (8 entities in total) |
Functional Keywords | cardiac myosin modulators inherited cardiomyopathies mavacamten, contractile protein |
Biological source | Bos taurus (cattle) |
Total number of polymer chains | 1 |
Total formula weight | 90337.06 |
Authors | Robert-Paganin, J.,Kikuti, C.,Auguin, D.,Rety, S.,David, A.,Houdusse, A. (deposition date: 2023-10-26, release date: 2023-12-13) |
Primary citation | Auguin, D.,Robert-Paganin, J.,Rety, S.,Kikuti, C.,David, A.,Theumer, G.,Schmidt, A.W.,Knolker, H.J.,Houdusse, A. Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction. Biorxiv, 2023 Cited by PubMed: 38014327DOI: 10.1101/2023.11.15.567213 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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