8QMH

Crystal structure of RNA G2C4 repeats in complex with small synthetic molecule ANP77

Summary for 8QMH

• Entry DOI: 10.2210/pdb8qmh/pdb
• Descriptor: RNA (5'-R(*GP*GP*CP*CP*CP*C)-3'), 3-(7-azanyl-1,8-naphthyridin-2-yl)-2-[(7-azanyl-1,8-naphthyridin-2-yl)methyl]-~{N}-(3-azanylpropyl)propanamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: rna, g2c4 repeats, als, ftd, hexanucleotide repeats
• Biological source: Homo sapiens
• Total number of polymer chains: 4
• Total formula weight: 8001.59

Authors

Kiliszek, A.,Ryczek, M.,Blaszczyk, L. (deposition date: 2023-09-22, release date: 2024-05-01, Last modification date: 2024-05-22)

• Primary citation: Blaszczyk, L.,Ryczek, M.,Das, B.,Mateja-Pluta, M.,Bejger, M.,Sliwiak, J.,Nakatani, K.,Kiliszek, A.; Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand.; Nucleic Acids Res., 2024; PubMed: 38738637; DOI: 10.1093/nar/gkae376

Experimental method

X-RAY DIFFRACTION (1.1 Å)