8QHQ

Crystal structure of human DNPH1 bound to hmdUMP

Summary for 8QHQ

• Entry DOI: 10.2210/pdb8qhq/pdb
• Related: 8QHR
• Descriptor: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: dnph1 n-glycosidase hmdump, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 100549.98

Authors

Rzechorzek, N.J.,West, S.C. (deposition date: 2023-09-09, release date: 2023-11-08)

• Primary citation: Rzechorzek, N.J.,Kunzelmann, S.,Purkiss, A.G.,Silva Dos Santos, M.,MacRae, J.I.,Taylor, I.A.,Fugger, K.,West, S.C.; Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.; Nat Commun, 14:6809-6809, 2023; PubMed: 37884503; DOI: 10.1038/s41467-023-42544-4

Experimental method

X-RAY DIFFRACTION (1.78 Å)