8Q1K

Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation

Summary for 8Q1K

• Entry DOI: 10.2210/pdb8q1k/pdb
• Descriptor: 5'-3' exonuclease PLD3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: pld3, structural biology, lysosome, dna/rna degradation, phospholipase d, 5' exonuclease, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 98624.54

Authors

Roske, Y.,Daumke, O.,Damme, M. (deposition date: 2023-07-31, release date: 2023-12-06, Last modification date: 2024-01-24)

• Primary citation: Roske, Y.,Cappel, C.,Cremer, N.,Hoffmann, P.,Koudelka, T.,Tholey, A.,Heinemann, U.,Daumke, O.,Damme, M.; Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.; Nucleic Acids Res., 52:370-384, 2024; PubMed: 37994783; DOI: 10.1093/nar/gkad1114

Experimental method

X-RAY DIFFRACTION (1.51 Å)