8PQK

APO crystal structure of PDGFRA-T674I kinase domain

Summary for 8PQK

Entry DOI	10.2210/pdb8pqk/pdb
Descriptor	Platelet-derived growth factor receptor alpha (2 entities in total)
Functional Keywords	pdgfra, protein kinase, tyrosine kinase, transmembrane receptor, platelet-derived growth factor, platelet-derived growth factor receptor, gist, gastrointestinal stromal tumors, cancer, gatekeeper mutant, gatekeeper mutation, p16234, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	40226.37
Authors	Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2023-07-11, release date: 2023-12-27, Last modification date: 2024-03-13)
Primary citation	Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D. Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15:63-63, 2024 Cited by PubMed: 38167404 DOI: 10.1038/s41467-023-44376-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation