8PQD

c-KIT kinase domain in complex with avapritinib derivative 10

Summary for 8PQD

Entry DOI	10.2210/pdb8pqd/pdb
Descriptor	Mast/stem cell growth factor receptor Kit, ~{N}-[(1~{S})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]ethanamide (3 entities in total)
Functional Keywords	c-kit protein kinase, avapritinib, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, p10721, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	75470.05
Authors	Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2023-07-11, release date: 2023-12-27, Last modification date: 2024-03-13)
Primary citation	Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D. Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15:63-63, 2024 Cited by PubMed: 38167404 DOI: 10.1038/s41467-023-44376-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation