8PNL

Outward-open conformation of a Major Facilitator Superfamily (MFS) transporter MHAS2168, a homologue of Rv1410 from M. tuberculosis, in complex with an alpaca nanobody

Summary for 8PNL

Entry DOI	10.2210/pdb8pnl/pdb
Descriptor	Putative triacylglyceride transporter, Nb_H2 (2 entities in total)
Functional Keywords	major facilitator superfamily transporter, nanobody, outward-open conformation, triacylglyceride extraction, transport protein
Biological source	Mycolicibacterium hassiacum DSM 44199 More
Total number of polymer chains	4
Total formula weight	140233.03
Authors	Remm, S.,Schoeppe, J.,Hutter, C.A.J.,Gonda, I.,Seeger, M.A. (deposition date: 2023-06-30, release date: 2023-10-18, Last modification date: 2023-10-25)
Primary citation	Remm, S.,De Vecchis, D.,Schoppe, J.,Hutter, C.A.J.,Gonda, I.,Hohl, M.,Newstead, S.,Schafer, L.V.,Seeger, M.A. Structural basis for triacylglyceride extraction from mycobacterial inner membrane by MFS transporter Rv1410. Nat Commun, 14:6449-6449, 2023 Cited by PubMed: 37833269 DOI: 10.1038/s41467-023-42073-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation