8P3E
Crystal structure of glucocerebrosidase in complex with allosteric activator
Summary for 8P3E
| Entry DOI | 10.2210/pdb8p3e/pdb |
| Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
| Functional Keywords | activator, lysosome, glycolipid metabolism, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 112578.01 |
| Authors | Schulze, M.-S. (deposition date: 2023-05-17, release date: 2024-03-06, Last modification date: 2024-04-24) |
| Primary citation | Schulze, M.E.D.,Scholz, D.,Jnoff, E.,Hall, A.,Melin, J.,Sands, Z.A.,Rodriguez, E.,Andre, V.M. Identification of ss-Glucocerebrosidase Activators for Glucosylceramide hydrolysis. Chemmedchem, 19:-, 2024 Cited by PubMed: 38381042DOI: 10.1002/cmdc.202300548 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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