8P2M

C. elegans TIR-1 protein.

Summary for 8P2M

Entry DOI	10.2210/pdb8p2m/pdb
EMDB information	17370
Descriptor	NAD(+) hydrolase tir-1 (1 entity in total)
Functional Keywords	sarm1; tir-1; c. elegans; neurodegeneration; cryo-em; structural biology; nad+ metabolism; axon wallerian degeneration, hydrolase
Biological source	Caenorhabditis elegans
Total number of polymer chains	9
Total formula weight	760465.55
Authors	Isupov, M.N.,Opatowsky, Y. (deposition date: 2023-05-16, release date: 2023-09-06)
Primary citation	Khazma, T.,Grossman, A.,Guez-Haddad, J.,Feng, C.,Dabas, H.,Sain, R.,Weitman, M.,Zalk, R.,Isupov, M.N.,Hammarlund, M.,Hons, M.,Opatowsky, Y. Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Rep, 42:113026-113026, 2023 Cited by PubMed: 37635352 DOI: 10.1016/j.celrep.2023.113026 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.82 Å)

Structure validation