8OZ3

Crystal structure of scFv ATOR 1017 bound to human 4-1BB

Summary for 8OZ3

Entry DOI	10.2210/pdb8oz3/pdb
Descriptor	Single chain Fv, Tumor necrosis factor receptor superfamily member 9, ... (4 entities in total)
Functional Keywords	complex, single chain fv, tumor necrosis factor, immune system
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	126341.00
Authors	Hakansson, M.,Von Schantz, L.,Rose, N. (deposition date: 2023-05-08, release date: 2024-03-13)
Primary citation	Enell Smith, K.,Fritzell, S.,Nilsson, A.,Barchan, K.,Rosen, A.,Schultz, L.,Varas, L.,Sall, A.,Rose, N.,Hakansson, M.,von Schantz, L.,Ellmark, P. ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1. Cancer Immunol.Immunother., 72:4145-4159, 2023 Cited by PubMed: 37796298 DOI: 10.1007/s00262-023-03548-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation