8OFK

Crystal structure of the cysteine-rich Gallus gallus urate oxidase in complex with the 8-azaxanthine inhibitor under reducing conditions (space group C 2 2 21)

This is a non-PDB format compatible entry.

Summary for 8OFK

• Entry DOI: 10.2210/pdb8ofk/pdb
• Descriptor: Uricase, 8-AZAXANTHINE, OXYGEN MOLECULE, ... (6 entities in total)
• Functional Keywords: cofactor-free oxidase, inhibitor, dioxygen binding, cysteine, oxidoreductase
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 4
• Total formula weight: 159281.21

Authors

Di Palma, M.,Chegkazi, M.,Bui, S.,Mori, G.,Percudani, R.,Steiner, R.A. (deposition date: 2023-03-15, release date: 2024-01-17)

• Primary citation: Mori, G.,Liuzzi, A.,Ronda, L.,Di Palma, M.,Chegkazi, M.S.,Bui, S.,Garcia-Maya, M.,Ragazzini, J.,Malatesta, M.,Della Monica, E.,Rivetti, C.,Antin, P.B.,Bettati, S.,Steiner, R.A.,Percudani, R.; Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism.; Mol.Biol.Evol., 40:-, 2023; PubMed: 37695804; DOI: 10.1093/molbev/msad200

Experimental method

X-RAY DIFFRACTION (1.713 Å)