8JYH

Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid C

Summary for 8JYH

Entry DOI	10.2210/pdb8jyh/pdb
Descriptor	Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, MANGANESE (II) ION, 7-[5-[(2~{S})-2-azanyl-3-oxidanyl-3-oxidanylidene-propyl]-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, ... (5 entities in total)
Functional Keywords	inhibitor, viral protein
Biological source	HIV-1 06TG.HT008 More
Total number of polymer chains	1
Total formula weight	17612.38
Authors	Ito, Y.,Lu, H.,Kitajima, M.,Ishikawa, H.,Nakata, Y.,Iwatani, Y.,Hoshino, T. (deposition date: 2023-07-03, release date: 2023-08-16, Last modification date: 2024-02-28)
Primary citation	Ito, Y.,Lu, H.,Kitajima, M.,Ishikawa, H.,Nakata, Y.,Iwatani, Y.,Hoshino, T. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86:2487-2495, 2023 Cited by PubMed: 37874155 DOI: 10.1021/acs.jnatprod.3c00662 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation