8JT9

Human VMAT2 complex with ketanserin

Summary for 8JT9

Entry DOI	10.2210/pdb8jt9/pdb
EMDB information	36637
Descriptor	Synaptic vesicular amine transporter, 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione (2 entities in total)
Functional Keywords	transporter1, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	49482.28
Authors	Jiang, D.H.,Wu, D. (deposition date: 2023-06-21, release date: 2023-11-29, Last modification date: 2024-02-21)
Primary citation	Wu, D.,Chen, Q.,Yu, Z.,Huang, B.,Zhao, J.,Wang, Y.,Su, J.,Zhou, F.,Yan, R.,Li, N.,Zhao, Y.,Jiang, D. Transport and inhibition mechanisms of human VMAT2. Nature, 626:427-434, 2024 Cited by PubMed: 38081299 DOI: 10.1038/s41586-023-06926-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.97 Å)

Structure validation