8JKK

Crystal Structure of the dioxygenase CcTet from Coprinopsis cinerea bound to 12bp 5-methylcytosine (5mC) containing duplex DNA

Summary for 8JKK

• Entry DOI: 10.2210/pdb8jkk/pdb
• Descriptor: 2OGFeDO JBP1/TET oxygenase domain-containing protein, DNA (5'-D(P*CP*GP*AP*TP*CP*(5CM)P*GP*CP*TP*AP*CP*G)-3'), DNA (5'-D(P*CP*GP*TP*AP*GP*CP*TP*GP*AP*TP*CP*G)-3'), ... (6 entities in total)
• Functional Keywords: dna demethylase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Hormographiella aspergillata); More
• Total number of polymer chains: 12
• Total formula weight: 215207.12

Authors

Zhang, L.,Zhang, L. (deposition date: 2023-06-01, release date: 2024-03-06, Last modification date: 2024-05-08)

• Primary citation: Zhang, L.,Mu, Y.,Li, T.,Hu, J.,Lin, H.,Zhang, L.; Molecular basis of an atypical dsDNA 5mC/6mA bifunctional dioxygenase CcTet from Coprinopsis cinerea in catalyzing dsDNA 5mC demethylation.; Nucleic Acids Res., 52:3886-3895, 2024; PubMed: 38324471; DOI: 10.1093/nar/gkae066

Experimental method

X-RAY DIFFRACTION (2.3 Å)