8JJB

Crystal structure of T2R-TTL-Y61 complex

Summary for 8JJB

Entry DOI	10.2210/pdb8jjb/pdb
Descriptor	Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... (13 entities in total)
Functional Keywords	microtubule, cell cycle
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	266760.12
Authors	Yang, J. (deposition date: 2023-05-30, release date: 2024-03-27)
Primary citation	Zhang, C.,Yan, W.,Liu, Y.,Tang, M.,Teng, Y.,Wang, F.,Hu, X.,Zhao, M.,Yang, J.,Li, Y. Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents. Eur.J.Med.Chem., 268:116265-116265, 2024 Cited by PubMed: 38430854 DOI: 10.1016/j.ejmech.2024.116265 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.68 Å)

Structure validation