8JHR

Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d

Summary for 8JHR

Entry DOI	10.2210/pdb8jhr/pdb
EMDB information	36285
Descriptor	Sphingosine-1-phosphate transporter SPNS2, 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine (2 entities in total)
Functional Keywords	transpoter, lipid transport
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	60965.44
Authors	Pang, B.,Yu, L.Y.,Ren, R.B. (deposition date: 2023-05-25, release date: 2024-01-10, Last modification date: 2024-02-14)
Primary citation	Pang, B.,Yu, L.,Li, T.,Jiao, H.,Wu, X.,Wang, J.,He, R.,Zhang, Y.,Wang, J.,Hu, H.,Dai, W.,Chen, L.,Ren, R. Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport. Cell Res., 34:173-176, 2024 Cited by PubMed: 38123824 DOI: 10.1038/s41422-023-00908-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.52 Å)

Structure validation