8J8G

Monkeypox virus DNA replication holoenzyme F8, A22 and E4 in complex with a DNA duplex and cidofovir diphosphate

Summary for 8J8G

• Entry DOI: 10.2210/pdb8j8g/pdb
• Related: 8HDZ 8HOY 8HPA 8J86 8J8F
• EMDB information: 36069
• Descriptor: DNA polymerase, E4R, DNA polymerase processivity factor component A20, ... (7 entities in total)
• Functional Keywords: monkeypox virus, dna replication holoenzyme, dna replication machinery, dna polymerase, b-family dna polymerase, uracil-dna glycosylase, mpxv, orthopoxvirus, poxviridae, dna processivity factor, dna, cdvpp, cidofovir diphosphate, viral protein
• Biological source: Monkeypox virus; More
• Total number of polymer chains: 5
• Total formula weight: 216732.48

Authors

Xu, Y.,Wu, Y.,Wu, X.,Zhang, Y.,Yang, Y.,Li, D.,Yang, B.,Gao, K.,Zhang, Z.,Dong, C. (deposition date: 2023-05-01, release date: 2024-05-08)

• Primary citation: Xu, Y.X.,Wu, Y.Q.,Wu, X.Y.,Zhang, Y.Y.,Yang, Y.X.,Li, D.Y.,Yang, B.,Gao, K.,Zhang, Z.Y.,Dong, C.J.; Structural basis of human monkeypox viral DNA replication inhibition by brincidofovir and cidofovir; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.79 Å)