8J4F

Structure of human Nav1.7 in complex with Hardwickii acid

Summary for 8J4F

• Entry DOI: 10.2210/pdb8j4f/pdb
• EMDB information: 35975
• Descriptor: Sodium channel protein type 9 subunit alpha, Sodium channel subunit beta-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: inhibitor complex., membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 268610.84

Authors

Wu, Q.R.,Yan, N. (deposition date: 2023-04-19, release date: 2023-06-14)

• Primary citation: Wu, Q.,Huang, J.,Fan, X.,Wang, K.,Jin, X.,Huang, G.,Li, J.,Pan, X.,Yan, N.; Structural mapping of Na v 1.7 antagonists.; Nat Commun, 14:3224-3224, 2023; PubMed: 37270609; DOI: 10.1038/s41467-023-38942-3

Experimental method

ELECTRON MICROSCOPY (3 Å)