8J1H

Agonist1 and Ruthenium Red bound state of mTRPV4

Summary for 8J1H

Entry DOI	10.2210/pdb8j1h/pdb
EMDB information	35922
Descriptor	Transient receptor potential cation channel subfamily V member 4, 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one (2 entities in total)
Functional Keywords	mtrpv4, structural protein, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	304460.24
Authors	Zhen, W.X.,Yang, F. (deposition date: 2023-04-12, release date: 2023-08-09)
Primary citation	Zhen, W.,Zhao, Z.,Chang, S.,Chen, X.,Wan, Y.,Yang, F. Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9:70-70, 2023 Cited by PubMed: 37429860 DOI: 10.1038/s41421-023-00579-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.88 Å)

Structure validation