8J1B

GSK101 and Ruthenium Red bound state of mTRPV4

Summary for 8J1B

Entry DOI	10.2210/pdb8j1b/pdb
EMDB information	35918
Descriptor	Transient receptor potential cation channel subfamily V member 4, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (3 entities in total)
Functional Keywords	mtrpv4, structural protein, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	321628.70
Authors	Zhen, W.X.,Yang, F. (deposition date: 2023-04-12, release date: 2023-08-09)
Primary citation	Zhen, W.,Zhao, Z.,Chang, S.,Chen, X.,Wan, Y.,Yang, F. Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9:70-70, 2023 Cited by PubMed: 37429860 DOI: 10.1038/s41421-023-00579-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.72 Å)

Structure validation