8IJW

Cryo-EM structure of the gastric proton pump with bound DQ-06

Summary for 8IJW

• Entry DOI: 10.2210/pdb8ijw/pdb
• EMDB information: 35501
• Descriptor: Sodium/potassium-transporting ATPase subunit alpha, Potassium-transporting ATPase subunit beta, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (8 entities in total)
• Functional Keywords: p-type atpase, proton pump, gastric, p2-type atpase, membrane protein
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 2
• Total formula weight: 153173.69

Authors

Abe, K.,Yokoshima, S.,Yoshimori, A. (deposition date: 2023-02-28, release date: 2023-08-30, Last modification date: 2023-10-04)

• Primary citation: Abe, K.,Ozako, M.,Inukai, M.,Matsuyuki, Y.,Kitayama, S.,Kanai, C.,Nagai, C.,Gopalasingam, C.C.,Gerle, C.,Shigematsu, H.,Umekubo, N.,Yokoshima, S.,Yoshimori, A.; Deep learning driven de novo drug design based on gastric proton pump structures.; Commun Biol, 6:956-956, 2023; PubMed: 37726448; DOI: 10.1038/s42003-023-05334-8

Experimental method

ELECTRON MICROSCOPY (2.19 Å)