8II0

FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine

Summary for 8II0

• Entry DOI: 10.2210/pdb8ii0/pdb
• Descriptor: Hypoxia-inducible factor 1-alpha inhibitor, 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, ... (6 entities in total)
• Functional Keywords: factor-inhibiting hypoxia-inducible factor, fih, 2og dependent dioxygenase, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41720.13

Authors

Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J. (deposition date: 2023-02-24, release date: 2024-02-28)

• Primary citation: Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J.; A small-molecule FIH inhibitor binding to a tyrosine-flip pocket ameliorates obesity and MAFLD; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.04 Å)